Renal excretion of unchanged modafinil ordinarily accounts for under 10% of the oral dose. Because of this when modafinil is taken by mouth, lower than ten% on the drug is eliminated from the body in the urine devoid of remaining metabolized from the liver or other organs.

A 2020 assessment reported that modafinil features a modest effect on memory updating, nevertheless the result is compact and could not properly reflect the perception that it is useful being a cognitive enhancer, as You can find inadequate proof to help such a claim.[249] Write-up-anesthesia sedation[edit]

acetazolamide will improve the amount or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.

Do not halt utilizing your CPAP equipment through snooze Except if your medical professional lets you know to. The combination of treatment method with CPAP and Provigil may very well be needed to very best deal with your affliction.

FYCOMPA is often a prescription drugs utilized by yourself or with other medicines to take care of partial-onset seizures with or without secondarily generalized seizures in individuals with epilepsy aged four and older and with other medicines to take care of Major generalized tonic-clonic seizures in individuals with epilepsy aged 12 and older. Vital SAFETY Details

Result of coadministration of a twin CYP3A4 and CYP2C19 inhibitor with fedratinib hasn't been researched.

[eighteen]  Critical renal and/or hepatic impairment is known to induce considerably increased constant-condition drug concentrations. Dose reduction is usually recommended in individuals with critical hepatic impairment.

crizotinib will increase amounts of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Dose reduction can be wanted for coadministered drugs which have been predominantly metabolized by CYP3A.

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modafinil will raise the degree or influence of diazepam intranasal by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Robust or average CYP2C19 inhibitors may well lessen price of diazepam elimination, therefore escalating adverse reactions to diazepam.

Other drugs may perhaps connect with modafinil, like prescription and more than-the-counter medicines, vitamins, and herbal solutions. Explain to Each and every of your well being treatment suppliers about all medicines you use now and any medication you start or prevent working with.

cannabidiol will enhance the degree or influence of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep track of Intently. Take into account decreasing the dose of delicate CYP2C19 substrates, as clinically proper, when coadministered with cannabidiol.

fedratinib will raise the level or outcome of modafinil by more info impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Watch. Modify dose of drugs that happen to be CYP2C19 substrates as required.

Although modafinil is usually identified for being Protected and considerable adverse results are uncommon, which includes in pediatric narcolepsy circumstances (sleep disorders in children), There's evidence that extensive-time period utilization can cause tolerance in some individuals.